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Ir J Med Sci ; 190(1): 403-409, 2021 Feb.
Artículo en Inglés | MEDLINE | ID: covidwho-629552

RESUMEN

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for coronavirus disease 19 (COVID-19), has rapidly spread since December 2019 to become the focus of healthcare systems worldwide. Its highly contagious nature and significant mortality has led to its prioritization as a public health issue. The race to prevent and treat this disease has led to "off-label" prescribing of medications such as hydroxychloroquine, azithromycin, and Kaletra (lopinavir/ritonavir). Currently, there is no robust clinical evidence for the use of these drugs in the treatment of COVID-19, with most, if not all of these medications associated with the potential for QT interval prolongation, torsades de pointes, and resultant drug-induced sudden cardiac death. The aim of this document is to help healthcare providers mitigate the potential deleterious effects of drug-induced QTc prolongation.


Asunto(s)
Antibacterianos/efectos adversos , Antivirales/efectos adversos , Azitromicina/efectos adversos , Tratamiento Farmacológico de COVID-19 , Hidroxicloroquina/efectos adversos , Síndrome de QT Prolongado/inducido químicamente , Lopinavir/efectos adversos , Ritonavir/efectos adversos , Torsades de Pointes/inducido químicamente , Combinación de Medicamentos , Electrocardiografía , Inhibidores Enzimáticos/efectos adversos , Humanos , Síndrome de QT Prolongado/sangre , Síndrome de QT Prolongado/diagnóstico , Síndrome de QT Prolongado/prevención & control , Magnesio/sangre , Pandemias , Potasio/sangre , Guías de Práctica Clínica como Asunto , Medición de Riesgo , Factores de Riesgo , SARS-CoV-2
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